Pub. Date : 1992
PMID : 1395933
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PLC-gamma 1 contains three tyrosine phosphorylation sites, which have been identified as residues 771, 783 and 1254. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 2 | Phosphorylation of tyrosine residues is sufficient to increase the catalytic activity of PLC-gamma 1, though other proteins may modulate this activation. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 3 | In vitro studies of PLC-gamma 1, recovered from growth factor-treated cells, indicate that activation by tyrosine phosphorylation is not due to increased sensitivity to Ca2+, a required co-factor, but is reflected in altered kinetic constants, i.e. V(max) and, to a lesser extent, Km. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |