Pub. Date : 1992 Mar
PMID : 1372480
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition by sodium nitroprusside or PGE1 of tyrosine phosphorylation induced in platelets by thrombin or ADP. | Nitroprusside | coagulation factor II, thrombin | Homo sapiens |
| 2 | Tyrosine phosphorylation in platelets activated by alpha-thrombin (1 nM) was inhibited by prostaglandin (PG) E1 (2 microM) or by sodium nitroprusside (100 microM). | Nitroprusside | coagulation factor II, thrombin | Homo sapiens |
| 3 | On the other hand, a higher concentration of alpha-thrombin (10 nM) induced tyrosine phosphorylation of the same proteins, elevation of [Ca2+]i, platelet aggregation, and serotonin secretion, irrespective of pretreatment of platelets by either PGE1 or sodium nitroprusside. | Nitroprusside | coagulation factor II, thrombin | Homo sapiens |
| 4 | Inhibition by sodium nitroprusside of tyrosine phosphorylation induced by alpha-thrombin (1 nM) was accompanied by an increased concentration of cGMP. | Nitroprusside | coagulation factor II, thrombin | Homo sapiens |