Title : Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1.

Pub. Date : 1992 Jan 25

PMID : 1370476






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1. Cyclic AMP phospholipase C gamma 1 Homo sapiens
2 Prior incubation of Jurkat cells with PMA or forskolin, which increases intracellular cAMP concentrations, prevented tyrosine phosphorylation of PLC-gamma 1 as well as the hydrolysis of PtdIns 4,5-P2 induced by ligation of CD3. Cyclic AMP phospholipase C gamma 1 Homo sapiens
3 These results suggest that the inhibition of PtdIns 4,5-P2 hydrolysis by PMA and cAMP is attributable to reduced tyrosine phosphorylation of PLC-gamma 1. Cyclic AMP phospholipase C gamma 1 Homo sapiens