Title : Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296.

Pub. Date : 1992 Oct 1

PMID : 1357660






2 Functional Relationships(s)
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1 Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296. Glutamic Acid leukotriene A4 hydrolase Homo sapiens
2 In conclusion, the results of the present study indicate a direct catalytic role for Glu-296 in the peptidase reaction of LTA4 hydrolase, where it presumably acts as a base to polarize water, whereas its function, if any, is apparently not essential in the epoxide hydrolase reaction. Glutamic Acid leukotriene A4 hydrolase Homo sapiens