Title : Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures.

Pub. Date : 1992 Aug 15

PMID : 1355650






1 Functional Relationships(s)
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1 Trypanothione reductase, an essential component of the anti-oxidant defences of parasitic trypanosomes and Leishmania, differs markedly from the equivalent host enzyme, glutathione reductase, in the binding site for the disulphide substrate. disulphide glutathione-disulfide reductase Homo sapiens