| Protein Name | glutathione-disulfide reductase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2936 |
| Gene Symbol | GSR |
| UniProt | P00390 (GSHR_HUMAN), V9HW90 (V9HW90_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
700
Total Number of Articles : 1054 |
Description |
glutathione-disulfide reductase |
| Gene Summary |
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010] |
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| Properties | |