Protein Name glutathione-disulfide reductase
Organism Homo sapiens
Gene ID 2936
Gene Symbol


UniProt P00390 (GSHR_HUMAN), V9HW90 (V9HW90_HUMAN)
Relationships Total Number of functionally related compound(s) : 700
Total Number of Articles : 1054

glutathione-disulfide reductase

Gene Summary

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]

  • glutathione reductase, mitochondrial
  • GRase
  • epididymis luminal protein 75
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