Title : Classification of the beta-adrenoceptor subtype in the rat portal vein: effect of altered thyroid hormone levels.

Pub. Date : 1992 Mar 3

PMID : 1350995






2 Functional Relationships(s)
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1 The potencies of the beta 1-adrenoceptor agonist, noradrenaline, and the beta 2-adrenoceptor agonist, fenoterol, at beta-adrenoceptors in portal vein were examined using preparations isolated from control, methimazole-treated or l-thyroxine-treated rats. Fenoterol adrenoceptor beta 2 Rattus norvegicus
2 The beta 2-adrenoceptor antagonist, ICI 118,551, was approximately 3000 fold more potent than the beta 1-adrenoceptor antagonist, atenolol, in blocking the effects of fenoterol (pA2 9.32 and 5.88 respectively) and 400 times more potent in antagonising noradrenaline (pA2 8.96 vs. 6.23). Fenoterol adrenoceptor beta 2 Rattus norvegicus