Title : Regulated expression of the tyrosine hydroxylase gene by membrane depolarization. Identification of the responsive element and possible second messengers.

Pub. Date : 1992 Apr 15

PMID : 1348505






2 Functional Relationships(s)
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1 The depolarization responsive element in the TH gene was mapped to the region containing the cAMP responsive element. Cyclic AMP tyrosine hydroxylase Rattus norvegicus
2 Interestingly, combined treatment with cAMP analogs and membrane depolarization had a greater effect than either alone on TH mRNA levels, as well as on CAT activity in PC12 cells transfected with the plasmid containing the cAMP responsive element. Cyclic AMP tyrosine hydroxylase Rattus norvegicus