Title : Potentiation of cyclic adenosine monophosphate production by thrombin in the human erythroleukemia cell line, HEL.

Pub. Date : 1992 Nov

PMID : 1331412






1 Functional Relationships(s)
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1 As opposed to its predominantly inhibitory effects on cyclic AMP production in platelets or in membranes from HEL cells, our initial experiments in intact HEL cells revealed that thrombin markedly potentiated the cyclic AMP response to prostaglandin E1 (2.9 +/- 0.2-fold), prostacyclin (1.9 +/- 0.2-fold) and carbacyclin (2.5 +/- 0.5-fold), measured either by radioimmunoassay or by the [3H]adenine preloading procedure. carboprostacyclin coagulation factor II, thrombin Homo sapiens