Title : ADF (adult T cell leukemia-derived factor)/human thioredoxin and viral infection: possible new therapeutic approach.

Pub. Date : 1992

PMID : 1329444






5 Functional Relationships(s)
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1 To clarify the role of ADF/thioredoxin system in the viral transformation, we tested the effect of 13-cis-retinoic acid (RA), which is a competitive inhibitor of thioredoxin reductase, on the growth of ADF high producing cells. Isotretinoin thioredoxin Homo sapiens
2 RA dose-dependently reduced the cell number and viability of ADF high producing lymphoid cells. Isotretinoin thioredoxin Homo sapiens
3 It is suggested that RA has an inhibitory effect on the activation and the growth of cells producing ADF and that inhibition of the ADF/thioredoxin system may be a new therapeutic approach for retrovirus-related disorders. Isotretinoin thioredoxin Homo sapiens
4 It is suggested that RA has an inhibitory effect on the activation and the growth of cells producing ADF and that inhibition of the ADF/thioredoxin system may be a new therapeutic approach for retrovirus-related disorders. Isotretinoin thioredoxin Homo sapiens
5 It is suggested that RA has an inhibitory effect on the activation and the growth of cells producing ADF and that inhibition of the ADF/thioredoxin system may be a new therapeutic approach for retrovirus-related disorders. Isotretinoin thioredoxin Homo sapiens