Title : Role of protein phosphatases in insulin-like growth factor II (IGF II)-stimulated mannose 6-phosphate/IGF II receptor redistribution.

Pub. Date : 1992 Aug 25

PMID : 1324932






2 Functional Relationships(s)
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1 Incubation of human fibroblasts with okadaic acid, a specific inhibitor of this phosphatase, resulted in a depletion of M6P/IGF II receptors at the cell surface without affecting their internalization kinetics. Okadaic Acid insulin like growth factor 2 Homo sapiens
2 While the decreased cell surface expression of receptors was reversible upon removal of okadaic acid the IGF II-induced redistribution of M6P/IGF II receptors to the plasma membrane (Braulke, T., Tippmer, S., Neher, E., and von Figura, K. (1989) EMBO J. Okadaic Acid insulin like growth factor 2 Homo sapiens