Title : Hepatocyte cytotoxicity induced by various hepatotoxins mediated by cytochrome P-450IIE1: protection with diethyldithiocarbamate administration.

Pub. Date : 1992 Feb

PMID : 1311644






2 Functional Relationships(s)
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1 Microsomes isolated from P-450IIE1-induced liver were also much more effective at catalysing a NADPH-dependent metabolism of CCl4 and DMN. NADP C-C motif chemokine ligand 4 Rattus norvegicus
2 The P-450IIE1 antibody markedly inhibited the NADPH-dependent metabolism of these compounds indicating that IIE1 is a major catalyst of the microsomal metabolism of CCl4 and DMN. NADP C-C motif chemokine ligand 4 Rattus norvegicus