Title : Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression.

Pub. Date : 1992 Jan 1

PMID : 1309222






4 Functional Relationships(s)
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1 The reduced accumulation of daunorubicin in the SW-1573/2R120 and GLC4/ADR cells was accompanied by a lower initial (2 min) uptake rate of this drug. Daunorubicin aldo-keto reductase family 1 member B Homo sapiens
2 However, daunorubicin was extruded 5-fold faster from GLC4/ADR cells than from the parental cells. Daunorubicin aldo-keto reductase family 1 member B Homo sapiens
3 In the presence of the energy metabolism inhibitors sodium azide and deoxyglucose, the reduced daunorubicin accumulations in the SW-1573/2R120 and GLC4/ADR MDR cells were (almost) completely reversed. Daunorubicin aldo-keto reductase family 1 member B Homo sapiens
4 Also, the enhanced efflux of daunorubicin from GLC4/ADR cells was inhibited. Daunorubicin aldo-keto reductase family 1 member B Homo sapiens