Pub. Date : 1992 Mar-Apr
PMID : 1307918
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of a cholecystokinin antagonist, proglumide, on cholecystokinin-8-induced gallbladder contraction in conscious dogs. | Proglumide | cholecystokinin | Canis lupus familiaris |
| 2 | Effect of a cholecystokinin antagonist, proglumide, on cholecystokinin-8-induced gallbladder contraction in conscious dogs. | Proglumide | cholecystokinin | Canis lupus familiaris |
| 3 | The objective of this study was to characterize the effect of proglumide, a cholecystokinin (CCK) antagonist, on gallbladder contraction stimulated by CCK in conscious dogs. | Proglumide | cholecystokinin | Canis lupus familiaris |
| 4 | The objective of this study was to characterize the effect of proglumide, a cholecystokinin (CCK) antagonist, on gallbladder contraction stimulated by CCK in conscious dogs. | Proglumide | cholecystokinin | Canis lupus familiaris |
| 5 | The objective of this study was to characterize the effect of proglumide, a cholecystokinin (CCK) antagonist, on gallbladder contraction stimulated by CCK in conscious dogs. | Proglumide | cholecystokinin | Canis lupus familiaris |
| 6 | The results of this study show that proglumide, given as an intravenous bolus (2.5, 5, 10, 20, and 40 mg/kg) or as a continuous intravenous infusion (150 or 300 mg/kg/h, 10 min), can block the stimulatory action of CCK in a dose-related manner. | Proglumide | cholecystokinin | Canis lupus familiaris |
| 7 | Bolus administration of proglumide resulted in a transient inhibition, whereas continuous infusion of proglumide resulted in a prolonged antagonism of CCK-stimulated gallbladder contraction. | Proglumide | cholecystokinin | Canis lupus familiaris |
| 8 | Review of the data leads to the conclusion that the antagonistic action of intravenously administered proglumide on CCK-stimulated gallbladder contraction may be characterized as rapid and reversible. | Proglumide | cholecystokinin | Canis lupus familiaris |