Title : PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity.

Pub. Date : 2003 Sep

PMID : 12975478






1 Functional Relationships(s)
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1 Induction of the hepatic expression of Srebp1c and of its target genes involved in fatty acid/triglyceride synthesis by fasting and refeeding or by hepatic expression of an active form of PI3K was inhibited in L-lambdaKO mice compared with that in control animals. Fatty Acids sterol regulatory element binding transcription factor 1 Mus musculus