Title : Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation.

Pub. Date : 2003 Nov 21

PMID : 12966092






1 Functional Relationships(s)
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1 Experiments with the Src inhibitor, PP2, and the antioxidant N-acetyl-L-cysteine revealed critical roles for Src and reactive oxygen species as upstream mediators of EGFR transactivation in response to PPAR ligands. Reactive Oxygen Species epidermal growth factor receptor Homo sapiens