Title : Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells.

Pub. Date : 2003 Sep

PMID : 12958179






1 Functional Relationships(s)
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1 Taken together, these results support the notion that the endogenous PHGPx plays a pivotal role in the regulation of 12(S)-lipoxygenase and cyclooxygenase 1 activities by reducing the level of intracellular lipid hydroperoxides in arachidonate metabolism in A431 cells. Lipid Peroxides prostaglandin-endoperoxide synthase 1 Homo sapiens