Title : The inhibition of cyclin-dependent kinases induces differentiation of supernumerary hair cells and Deiters' cells in the developing organ of Corti.

Pub. Date : 2003 Nov

PMID : 12958157






4 Functional Relationships(s)
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1 In the embryonic day 19 organs of Corti, we showed that roscovitine, a chemical inhibitor of cyclin-dependent kinases (CDKs), significantly increased the number of hair cells (HCs) and corresponding supporting cells (SCs) by triggering differentiation of precursor cells without interacting with cell proliferation. Roscovitine cyclin dependent kinase 1 Homo sapiens
2 The effect of roscovitine was mimicked by other CDK1, 2, 5, and 7 inhibitors but not by CDK4/6 and mitogen-activated protein kinase pathway antagonists. Roscovitine cyclin dependent kinase 1 Homo sapiens
3 Immunohistochemical analysis indicated that roscovitine-specific intracellular targets, CDK1, 2, 5, and 7, were expressed in the organ of Corti and especially in Hensen"s cells. Roscovitine cyclin dependent kinase 1 Homo sapiens
4 Affinity chromatography studies showed a tight correlation between the protein levels of CDK1/2 and 5 and the rate of roscovitine-induced supernumerary cells in the organ of Corti. Roscovitine cyclin dependent kinase 1 Homo sapiens