Title : Schedule-dependent molecular effects of the proteasome inhibitor bortezomib and gemcitabine in pancreatic cancer.

Pub. Date : 2003 Jul

PMID : 12943815






1 Functional Relationships(s)
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1 Bortezomib treatment led to accumulation of p21(WAF1/CIP1) and p27(KIP1) and decreased BCL-2; gemcitabine decreased p27(KIP1), induced BCL-2 and had no effect on p21(WAF1/CIP1). gemcitabine cyclin dependent kinase inhibitor 1B Homo sapiens