Pub. Date : 2003 Jul
PMID : 12943808
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation. | sphingosine 1-phosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | This study examines the role of p38 mitogen-activated protein kinase (p38(MAPK)) in vascular smooth muscle cell migration after stimulation with S-1-P, and pathways leading to p38(MAPK) activation. | sphingosine 1-phosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | This study examines the role of p38 mitogen-activated protein kinase (p38(MAPK)) in vascular smooth muscle cell migration after stimulation with S-1-P, and pathways leading to p38(MAPK) activation. | sphingosine 1-phosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | This study examines the role of p38 mitogen-activated protein kinase (p38(MAPK)) in vascular smooth muscle cell migration after stimulation with S-1-P, and pathways leading to p38(MAPK) activation. | sphingosine 1-phosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | We hypothesized that S-1-P-induced VSMC migration is also dependent on p38(MAPK) activation through a G(i)-coupled extracellular receptor and phosphoinositide 3-kinase (PI3-K). | sphingosine 1-phosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | Western blotting was performed to examine p38(MAPK) activation in response to S-1-P with and without SB203580, AG1478, or inhibitors of G(i) (pertussis toxin), PI3-K (Wortmannin and LY294002), or MEK1 (PD98059). | sphingosine 1-phosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | Western blotting and immunoprecipitation for targets of p38(MAPK) (MAPKAP kinase-2) and PI3-K (Akt) were also performed.S-1-P stimulated migration of VSMCs in both wound and Boyden transwell assays. | sphingosine 1-phosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 8 | RESULTS: S-1-P stimulated activation of p38(MAPK) that peaked at 10 min, as well as activation of MAPKAP kinase-2. | sphingosine 1-phosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 9 | CONCLUSIONS: S-1-P induced VSMC migration through a G(i)-linked and a PI3-K coupled, p38(MAPK)- dependent process. | sphingosine 1-phosphate | mitogen-activated protein kinase 1 | Homo sapiens |
| 10 | S-1-P-stimulated activation of p38(MAPK) does not signal via transactivation of the EGF receptor. | sphingosine 1-phosphate | mitogen-activated protein kinase 1 | Homo sapiens |