Title : Gene-directed enzyme prodrug therapy for osteosarcoma: sensitization to CPT-11 in vitro and in vivo by adenoviral delivery of a gene encoding secreted carboxylesterase-2.

Pub. Date : 2003 Aug

PMID : 12939466






3 Functional Relationships(s)
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1 Gene-directed enzyme prodrug therapy for osteosarcoma: sensitization to CPT-11 in vitro and in vivo by adenoviral delivery of a gene encoding secreted carboxylesterase-2. Irinotecan carboxylesterase 2 Homo sapiens
2 GDEPT aims at high production of CE2 at the tumor site, resulting in efficient local conversion of CPT-11 into SN-38. Irinotecan carboxylesterase 2 Homo sapiens
3 GDEPT aims at high production of CE2 at the tumor site, resulting in efficient local conversion of CPT-11 into SN-38. Irinotecan carboxylesterase 2 Homo sapiens