Title : Response markers and the molecular mechanisms of action of Gleevec in gastrointestinal stromal tumors.

Pub. Date : 2003 Aug

PMID : 12939459






1 Functional Relationships(s)
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1 On a functional level, we demonstrated that imatinib inhibited phosphorylation of KIT, AKT, and extracellular signal-regulated kinase 1/2 without affecting the total level of these proteins and that differential expression of these response genes involved activation of mitogen-activated protein kinase-dependent and -independent pathways. Imatinib Mesylate mitogen-activated protein kinase 3 Homo sapiens