Title : Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity.

Pub. Date : 2003 Dec

PMID : 12937023






4 Functional Relationships(s)
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1 IL-6 was released from the leg already after 10 min of exercise in the glycogen-depleted state, whereas no significant release was observed at any time in the loaded state. Glycogen interleukin 6 Homo sapiens
2 After 60 min of exercise in the glycogen-depleted state, individual values of alpha2-AMPK activity correlated significantly (r = 0.87, P < 0.006) with individual values of IL-6 release as well as with average IL-6 release over the entire 60 min (r = 0.86, P < 0.006). Glycogen interleukin 6 Homo sapiens
3 After 60 min of exercise in the glycogen-depleted state, individual values of alpha2-AMPK activity correlated significantly (r = 0.87, P < 0.006) with individual values of IL-6 release as well as with average IL-6 release over the entire 60 min (r = 0.86, P < 0.006). Glycogen interleukin 6 Homo sapiens
4 Alternatively, both AMPK and IL-6 are independent sensors of a low muscle glycogen concentration during exercise. Glycogen interleukin 6 Homo sapiens