Title : High-throughput screening to estimate single or multiple enzymes involved in drug metabolism: microtitre plate assay using a combination of recombinant CYP2D6 and human liver microsomes.

Pub. Date : 2003 Aug

PMID : 12936703






1 Functional Relationships(s)
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1 The IC50 values of typical substrates of CYP2D6 (bufuralol and dextromethorphan at lower substrate concentration) in inhibition studies using HLM, were similar to those in the case of recombinant CYP2D6, but the values of the compounds that are metabolized by multiple CYP forms (perphenazine and chlorpromazine) in HLM were much larger. Dextromethorphan cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus