Pub. Date : 2003 Aug 20
PMID : 12930785
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The involvement of glucose metabolism in the regulation of inducible nitric oxide synthase gene expression in glial cells: possible role of glucose-6-phosphate dehydrogenase and CCAAT/enhancing binding protein. | Glucose | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | In rat glial cells the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) gene expression was enhanced by extracellular glucose concentration in a dose-dependent manner. | Glucose | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | In rat glial cells the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) gene expression was enhanced by extracellular glucose concentration in a dose-dependent manner. | Glucose | nitric oxide synthase 2 | Rattus norvegicus |
| 4 | On the other hand, 2-deoxy-d-glucose decreased the LPS-induced iNOS gene expression even in the presence of glucose (6 gm/l), suggesting that glucose metabolism is linked to the regulation of iNOS gene expression. | Glucose | nitric oxide synthase 2 | Rattus norvegicus |
| 5 | On the other hand, 2-deoxy-d-glucose decreased the LPS-induced iNOS gene expression even in the presence of glucose (6 gm/l), suggesting that glucose metabolism is linked to the regulation of iNOS gene expression. | Glucose | nitric oxide synthase 2 | Rattus norvegicus |
| 6 | Gel shift assays showed that CAAT/enhancing binding protein (C/EBP), rather than AP-1 or NF-kappaB, correlated better with a glucose-dependent increase in iNOS gene expression. | Glucose | nitric oxide synthase 2 | Rattus norvegicus |
| 7 | The cotransfection with wild-type C/EBP-delta increased the iNOS promoter activity to the level achieved with a higher glucose concentration in the presence of LPS. | Glucose | nitric oxide synthase 2 | Rattus norvegicus |
| 8 | Therefore, our results suggest that C/EBP-delta may be a critical mediator in glucose-mediated regulation of iNOS gene expression. | Glucose | nitric oxide synthase 2 | Rattus norvegicus |