Title : Direct effect of propylthiouracil on progesterone release in rat granulosa cells.

Pub. Date : 2003 Aug

PMID : 12922945






2 Functional Relationships(s)
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1 PTU (12 mM) inhibited the activities of both the cytochrome P450 side-chain cleavage enzyme (P450scc, conversion of 25-hydroxyl cholesterol to pregnenolone) and the 3beta-hydroxysteroid dehydrogenase (conversion of pregnenolone to progesterone) in rat granulosa cells. Propylthiouracil cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus
2 PTU (12 mM) inhibited the activities of both the cytochrome P450 side-chain cleavage enzyme (P450scc, conversion of 25-hydroxyl cholesterol to pregnenolone) and the 3beta-hydroxysteroid dehydrogenase (conversion of pregnenolone to progesterone) in rat granulosa cells. Propylthiouracil cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus