Pub. Date : 2003 Aug 1
PMID : 12907245
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide. | Vinblastine | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Vinblastine caused inactivation of ERK whereas ERK was unaffected in cells exposed to doxorubicin or VP-16. | Vinblastine | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Inhibition of ERK signaling by the MEK inhibitor, U0126, potentiated the cytotoxic effects of vinblastine and doxorubicin, but not that of VP-16. | Vinblastine | mitogen-activated protein kinase 1 | Homo sapiens |