Pub. Date : 2003 Aug 15
PMID : 12898515
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 9-cis retinoic acid accelerates calcitriol-induced osteocalcin production and promotes degradation of both vitamin D receptor and retinoid X receptor in human osteoblastic cells. | Alitretinoin | bone gamma-carboxyglutamate protein | Homo sapiens |
| 2 | In this study, we show that 9-cis retinoic acid (9-cisRA), the ligand for RXR, accelerates calcitriol-induced expression of osteocalcin gene, the marker for mature osteoblasts. | Alitretinoin | bone gamma-carboxyglutamate protein | Homo sapiens |
| 3 | In this study, we show that 9-cis retinoic acid (9-cisRA), the ligand for RXR, accelerates calcitriol-induced expression of osteocalcin gene, the marker for mature osteoblasts. | Alitretinoin | bone gamma-carboxyglutamate protein | Homo sapiens |
| 4 | In combination treatments, 9-cisRA rapidly stimulated osteocalcin mRNA synthesis induced by the different vitamin D(3) compounds. | Alitretinoin | bone gamma-carboxyglutamate protein | Homo sapiens |
| 5 | Furthermore, 9-cisRA increased the formation of RXRbeta-VDR-VDRE complex on the osteocalcin gene VDRE. | Alitretinoin | bone gamma-carboxyglutamate protein | Homo sapiens |
| 6 | These results suggest that 9-cisRA accelerates calcitriol-induced osteocalcin production in human osteoblastic cells through increased formation of transcriptionally active chromatin complexes and, subsequently, promotes degradation of the heterodimeric complex of VDR and RXR. | Alitretinoin | bone gamma-carboxyglutamate protein | Homo sapiens |