Pub. Date : 2003 Aug
PMID : 12897148
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we report that high-density-lipoprotein (HDL) cholesterol levels are increased in LXR-deficient mice, suggesting that derepression of ABCA1 and possibly other LXR target genes in selected tissues is sufficient to result in enhanced HDL biogenesis at the whole-body level. | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |
| 2 | Here we report that high-density-lipoprotein (HDL) cholesterol levels are increased in LXR-deficient mice, suggesting that derepression of ABCA1 and possibly other LXR target genes in selected tissues is sufficient to result in enhanced HDL biogenesis at the whole-body level. | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |
| 3 | These findings reveal differential requirements for corepressors in the regulation of genes involved in cholesterol and fatty acid homeostasis and raise the possibility that these interactions may be exploited to develop synthetic ligands that selectively modulate LXR actions in vivo. | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |