Title : Glycine modulates cytokine secretion, inhibits hepatic damage and improves survival in a model of endotoxemia in mice.

Pub. Date : 2003 Aug

PMID : 12895268






4 Functional Relationships(s)
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1 RESULTS: In the glycine-treated mice, the serum levels of liver enzymes and TNF-alpha, the histologic necroinflammation score and the mortality rate were significantly reduced compared to control mice (P<0.001). Glycine tumor necrosis factor Mus musculus
2 In vitro studies in cultured lymphocytes isolated from either normal or glycine pretreated mice, demonstrated a significant and dose-dependent inhibition of LPS-induced TNF-alpha secretion and increase in IL-10 response after treatment with glycine (P<0.01). Glycine tumor necrosis factor Mus musculus
3 In vitro studies in cultured lymphocytes isolated from either normal or glycine pretreated mice, demonstrated a significant and dose-dependent inhibition of LPS-induced TNF-alpha secretion and increase in IL-10 response after treatment with glycine (P<0.01). Glycine tumor necrosis factor Mus musculus
4 The protective effect of glycine is associated with modulation of TNF-alpha and IL-10 secretion. Glycine tumor necrosis factor Mus musculus