Pub. Date : 2003
PMID : 12890524
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Environmental context and drug history modulate amphetamine-induced c-fos mRNA expression in the basal ganglia, central extended amygdala, and associated limbic forebrain. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | When given in a novel test environment amphetamine produces greater levels of c-fos and arc mRNA expression in many brain regions relative to when it is given in the home cage. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | The purpose of the current study was to determine if environment and drug history interact to influence amphetamine-induced c-fos mRNA expression. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 4 | In most brain regions amphetamine given in the Novel environment produced greater c-fos mRNA expression than when given it was given at Home, and drug history had no effect on amphetamine-induced c-fos mRNA expression. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 5 | However, within the subthalamic nucleus, substantia nigra reticulata, and central nucleus of the amygdala prior experience with amphetamine in the Novel but not Home environment enhanced the effect of an amphetamine challenge injection on c-fos mRNA expression. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 6 | However, within the subthalamic nucleus, substantia nigra reticulata, and central nucleus of the amygdala prior experience with amphetamine in the Novel but not Home environment enhanced the effect of an amphetamine challenge injection on c-fos mRNA expression. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 7 | In contrast, there was a decrease in c-fos mRNA expression in amphetamine-pretreated animals, regardless of environmental context, in the ventral portion of the far caudal striatum. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 8 | Reexposure to an environment previously paired with amphetamine produced a conditioned increase in c-fos mRNA expression in portions of the caudate-putamen, the subthalamic nucleus, the nucleus accumbens shell and a conditioned decrease in c-fos mRNA expression in the central nucleus of the amygdala. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 9 | Reexposure to an environment previously paired with amphetamine produced a conditioned increase in c-fos mRNA expression in portions of the caudate-putamen, the subthalamic nucleus, the nucleus accumbens shell and a conditioned decrease in c-fos mRNA expression in the central nucleus of the amygdala. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |