Title : Attenuation of Kupffer cell activation in cold-preserved livers after pretreatment of rats with methylprednisolone or its macromolecular prodrug.

Pub. Date : 2003 Jul

PMID : 12880285






3 Functional Relationships(s)
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1 Pretreatment of rats with MP or DMP caused a significant (p < 0.0001) reduction in TNF-alpha AUC in the perfusate, with no significant differences between MP and DMP. Unithiol tumor necrosis factor Rattus norvegicus
2 The maximum inhibitory effect of MP (77.5 +/- 10.2%) was observed after 48 h of preservation, whereas DMP showed maximal inhibition of TNF-alpha AUC at both 24 (74.5 +/- 15.8%) and 48 (74.8 +/- 12.6%) h of preservation. Unithiol tumor necrosis factor Rattus norvegicus
3 CONCLUSIONS: Both MP and DMP pretreatments decreased the release of TNF-alpha and acid phosphatase from livers subjected to cold ischemia preservation. Unithiol tumor necrosis factor Rattus norvegicus