Pub. Date : 2003 Oct 3
PMID : 12874275
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases. | Glutathione | epidermal growth factor receptor | Rattus norvegicus |
| 2 | The mere depletion of GSH by application of diethyl maleate EGFR-dependently activated ERK and Akt, thus mimicking BQ effects. | Glutathione | epidermal growth factor receptor | Rattus norvegicus |
| 3 | In summary, EGFR-dependent signaling was mediated by protein-tyrosine phosphatase inactivation (menadione), GSH depletion (BQ), and redox-cycling (DMNQ), funneling into the same signaling pathway. | Glutathione | epidermal growth factor receptor | Rattus norvegicus |