Title : Role of reactive oxygen species in endothelin-induced hypertension.

Pub. Date : 2003 Oct

PMID : 12874096






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Endothelin-1 (5 pmol/kg per minute) was chronically infused into the jugular vein by use of mini-osmotic pump for 9 days in male Sprague-Dawley rats and in rats treated with the superoxide anion scavenger tempol (30 mg/kg per day). tempol endothelin 1 Rattus norvegicus
2 The increase in arterial pressure in response to endothelin-1 was completely abolished by tempol (127+/-4 versus 127+/-4 mm Hg). tempol endothelin 1 Rattus norvegicus
3 Tempol also significantly decreased the level of 8-isoprostaglandin F2alpha in the endothelin-1-treated rats. tempol endothelin 1 Rattus norvegicus