Title : The eukaryotic initiation factor 5A is involved in the regulation of proliferation and apoptosis induced by interferon-alpha and EGF in human cancer cells.

Pub. Date : 2003 Jun

PMID : 12869532






3 Functional Relationships(s)
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1 The latter effect was again antagonized by the addition of EGF to IFNalpha-pretreated cells, probably through the activation of the EGF-->ERK-dependent pathway, since the addition of the specific MEK-1 inhibitor PD098059 abrogated the recovery of intracellular hypusine content induced by EGF in IFNalpha-pretreated cancer cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one epidermal growth factor Homo sapiens
2 The latter effect was again antagonized by the addition of EGF to IFNalpha-pretreated cells, probably through the activation of the EGF-->ERK-dependent pathway, since the addition of the specific MEK-1 inhibitor PD098059 abrogated the recovery of intracellular hypusine content induced by EGF in IFNalpha-pretreated cancer cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one epidermal growth factor Homo sapiens
3 The latter effect was again antagonized by the addition of EGF to IFNalpha-pretreated cells, probably through the activation of the EGF-->ERK-dependent pathway, since the addition of the specific MEK-1 inhibitor PD098059 abrogated the recovery of intracellular hypusine content induced by EGF in IFNalpha-pretreated cancer cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one epidermal growth factor Homo sapiens