Title : Molecular mechanism for ATP-dependent closure of the K+ channel Kir6.2.

Pub. Date : 2003 Oct 1

PMID : 12860923






1 Functional Relationships(s)
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1 Based on these results and the recently published structure of Kir3.1 cytoplasmic domain, we propose a scheme where binding of the beta phosphate group of ATP to K185 induces a motion of the surrounding region, which destabilizes the open state, favouring closure of the M2 gate. Adenosine Triphosphate potassium inwardly rectifying channel subfamily J member 3 Homo sapiens