Title : Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes.

Pub. Date : 2003 Sep 19

PMID : 12855700






1 Functional Relationships(s)
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1 We here report that gene expression of sterol Delta8-isomerase (SI), which catalyzes the conversion of the 8-ene isomer into the 7-ene isomer in the last steps of the cholesterol biosynthetic pathway, is regulated by SREBPs, mainly by SREBP-2. Cholesterol sterol regulatory element binding transcription factor 2 Homo sapiens