Title : Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes.

Pub. Date : 2003 Jul 17

PMID : 12852754






1 Functional Relationships(s)
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1 Combination of both structural features provided 14c (p38: 0.34 microM, inhibition of CYP1A2 0%, 2C9 2.6%, 2C19 7.6% at 10 microM), which was selected for further development. Carbon-14 cytochrome P450 family 1 subfamily A member 2 Homo sapiens