Title : Phenobarbital-imprinted overinduction of adult constituent CYP isoforms.

Pub. Date : 2003 Aug

PMID : 12837975






1 Functional Relationships(s)
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1 The expression of the other isoforms was significantly elevated by both doses of phenobarbital (10 mg >1 mg), though CYP2C6, CYP3A1, and CYP3A2 levels were increased an additional 30-50% when the animals were neonatally exposed to the barbiturate, demonstrating for the first time that mechanisms regulating induction of constitutive CYPs in adults are imprintable at birth. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus