Title : The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation.

Pub. Date : 2003 Jul 15

PMID : 12837289






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here we demonstrate that treatment of vascular smooth muscle cells with angiotensin II results in activation of the Shc/Grb2/ERK2 signaling pathway as measured by (1) increased Shc tyrosine phosphorylation, (2) increased c-Src/Shc cellular co-localization, (3) increased Shc/Grb2 co-association, and (4) ERK2 activation. Tyrosine angiotensinogen Homo sapiens