Title : Glial HO-1 expression, iron deposition and oxidative stress in neurodegenerative diseases.

Pub. Date : 1999 Sep

PMID : 12835114






2 Functional Relationships(s)
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Protein Name
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1 The effects of dopamine on HO-1 expression were inhibited by ascorbate implicating a free radical mechanism of action. Dopamine heme oxygenase 1 Homo sapiens
2 Dopamine-induced mitochondrial iron trapping was abrogated by administration of the heme oxygenase inhibitors, tin mesoporphyrin (SnMP) or dexamethasone (DEX) indicating that HO-1 upregulation is necessary for subsequent mitochondrial iron deposition in these cells. Dopamine heme oxygenase 1 Homo sapiens