Pub. Date : 2003 Jun
PMID : 12826984
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Two enzyme systems have been implicated in ziprasidone metabolism: the cytosolic enzyme, aldehyde oxidase, catalyzes the predominant reductive pathway, and cytochrome P4503A4 (CYP3A4) is responsible for two alternative oxidation pathways. | ziprasidone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Two enzyme systems have been implicated in ziprasidone metabolism: the cytosolic enzyme, aldehyde oxidase, catalyzes the predominant reductive pathway, and cytochrome P4503A4 (CYP3A4) is responsible for two alternative oxidation pathways. | ziprasidone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Because CYP3A4 only mediates one third of ziprasidone metabolism, the likelihood of interactions between ziprasidone and CYP3A4 inhibitors/ substrates is low. | ziprasidone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |