Pub. Date : 2003 Jul
PMID : 12824263
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High glucose-induced tyrosine nitration in endothelial cells: role of eNOS uncoupling and aldose reductase activation. | Glucose | aldo-keto reductase family 1 member B | Homo sapiens |
| 2 | The effects of glucose were more potent: Inhibiting NOS or aldose reductase (AR), scavenging superoxide or peroxynitrite, or supplementing the NOS substrate L-arginine or cofactor tetrahydrobiopterin blocked the formation of reactive oxygen species and prevented protein tyrosine nitration. | Glucose | aldo-keto reductase family 1 member B | Homo sapiens |
| 3 | The effects of glucose were more potent: Inhibiting NOS or aldose reductase (AR), scavenging superoxide or peroxynitrite, or supplementing the NOS substrate L-arginine or cofactor tetrahydrobiopterin blocked the formation of reactive oxygen species and prevented protein tyrosine nitration. | Glucose | aldo-keto reductase family 1 member B | Homo sapiens |
| 4 | CONCLUSIONS: Increases in glucose levels and osmotic stress similar to those in diabetic patients increase the formation of nitrotyrosine in retinal endothelial cells because of their actions increasing NOS activity and causing superoxide formation due to eNOS uncoupling and AR activation. | Glucose | aldo-keto reductase family 1 member B | Homo sapiens |