Title : The suppressed expression and functional activity of hepatic P-glycoprotein in rats with protein-calorie malnutrition.

Pub. Date : 2003 Jul

PMID : 12820137






1 Functional Relationships(s)
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1 The in vivo canalicular excretion clearance (CL(exc)) of daunomycin was also decreased by 79% (p < 0.01) in PCM rats, but the degree was more severe than would be expected from the 22% decrease in the expression of P-gp and the 33% decrease in the uptake of daunomycin (CL(int)). Daunorubicin ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus