Pub. Date : 1992 Dec 15
PMID : 1281039
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enhancement of xanthine dehydrogenase mediated mitomycin C metabolism by dicumarol. | Mitomycin | xanthine dehydrogenase | Homo sapiens |
| 2 | These studies examined the effect of dicumarol on xanthine dehydrogenase (XDH), an enzyme recently shown to bioreduce mitomycin C. | Mitomycin | xanthine dehydrogenase | Homo sapiens |
| 3 | These studies examined the effect of dicumarol on xanthine dehydrogenase (XDH), an enzyme recently shown to bioreduce mitomycin C. | Mitomycin | xanthine dehydrogenase | Homo sapiens |
| 4 | Dicumarol, which has previously been shown to inhibit xanthine oxidase (XO), inhibited both XDH and XO mediated conversion of xanthine to uric acid but potentiated the metabolism of mitomycin C by XDH and XO. | Mitomycin | xanthine dehydrogenase | Homo sapiens |
| 5 | Formation of 2,7-diaminomitosene following mitomycin C bioactivation by XDH was increased 3-fold aerobically and 4-fold hypoxically when 20 microM dicumarol was included in the reaction mixture. | Mitomycin | xanthine dehydrogenase | Homo sapiens |