Pub. Date : 2003 Jul
PMID : 12808176
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Heparin inhibits prothrombotic tissue factor (TF) and releases its inhibitor, tissue factor pathway inhibitor (TFPI), from the endothelium, but repeated administration of heparin depletes vascular stores of TFPI. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 2 | BACKGROUND: Heparin inhibits prothrombotic tissue factor (TF) and releases its inhibitor, tissue factor pathway inhibitor (TFPI), from the endothelium, but repeated administration of heparin depletes vascular stores of TFPI. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 3 | BACKGROUND: Heparin inhibits prothrombotic tissue factor (TF) and releases its inhibitor, tissue factor pathway inhibitor (TFPI), from the endothelium, but repeated administration of heparin depletes vascular stores of TFPI. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 4 | BACKGROUND: Heparin inhibits prothrombotic tissue factor (TF) and releases its inhibitor, tissue factor pathway inhibitor (TFPI), from the endothelium, but repeated administration of heparin depletes vascular stores of TFPI. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 5 | BACKGROUND: Heparin inhibits prothrombotic tissue factor (TF) and releases its inhibitor, tissue factor pathway inhibitor (TFPI), from the endothelium, but repeated administration of heparin depletes vascular stores of TFPI. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 6 | BACKGROUND: Heparin inhibits prothrombotic tissue factor (TF) and releases its inhibitor, tissue factor pathway inhibitor (TFPI), from the endothelium, but repeated administration of heparin depletes vascular stores of TFPI. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 7 | In patients switched to UFH, TF levels remained unchanged compared with pre-randomization values, TFPI increased at each interval of HD sessions (all P<0.035) and PF 1+2 increased pre-dialysis (P=0.015). | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 8 | In contrast, baseline TFPI and its 10-min rise correlated inversely with the UFH loading dose (both P<0.040). | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 9 | CONCLUSIONS: Depletion of heparin-releasable stores of TFPI is an untoward effect of repeated anticoagulation during maintenance HD therapy. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 10 | The traditional UFH regimen is more prothrombotic than single enoxaparin injections, with high loading doses of UFH being involved in TFPI exhaustion and subsequent hypercoagulability. | Heparin | tissue factor pathway inhibitor | Homo sapiens |