Title : Urinary excretion of the uraemic toxin p-cresol in the rat: contribution of glucuronidation to its metabolization.

Pub. Date : 2003 Jul

PMID : 12808165






3 Functional Relationships(s)
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1 Addition of beta-glucuronidase to urine samples and incubation at 37 degrees C resulted in a marked decrease in the unidentified peak height (P<0.001) together with an increase in p-cresol peak height (P<0.001), suggesting that the unidentified peak was composed, at least in part, of p-cresylglucuronide. 4-cresol glucuronidase, beta Rattus norvegicus
2 Linear regression between the peak height of p-cresylglucuronide before enzyme treatment and the increase in p-cresol peak height after enzyme treatment in samples incubated with beta-glucuronidase allowed us to calculate the amount of p-cresylglucuronide as its p-cresol equivalents. 4-cresol glucuronidase, beta Rattus norvegicus
3 Linear regression between the peak height of p-cresylglucuronide before enzyme treatment and the increase in p-cresol peak height after enzyme treatment in samples incubated with beta-glucuronidase allowed us to calculate the amount of p-cresylglucuronide as its p-cresol equivalents. 4-cresol glucuronidase, beta Rattus norvegicus