Title : Suppressive activities of OGG1 and MYH proteins against G:C to T:A mutations caused by 8-hydroxyguanine but not by benzo[a]pyrene diol epoxide in human cells in vivo.

Pub. Date : 2003 Jun

PMID : 12807753






2 Functional Relationships(s)
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1 In this study, we assessed the abilities of OGG1, MYH and APE1 proteins, which are components of a base excision repair pathway, to suppress G:C to T:A transversions caused by 8OHG or BPDE by a bacterial suppressor tRNA (supF) forward mutation assay using a shuttle plasmid, pMY189. 8ohg 8-oxoguanine DNA glycosylase Homo sapiens
2 These results indicate that OGG1 and MYH function as suppressors for G:C to T:A transversions by 8OHG but not by BPDE in human cells. 8ohg 8-oxoguanine DNA glycosylase Homo sapiens