Title : Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.

Pub. Date : 2003 Jul

PMID : 12807725






1 Functional Relationships(s)
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1 Benzo[a]pyrene, another potent carcinogen of CS, can also activate NF-kappaB, but by an as yet unknown mechanism. Benzo(a)pyrene nuclear factor kappa B subunit 1 Homo sapiens