Title : Involvement of MAP kinases in TGF-beta-stimulated vascular endothelial growth factor synthesis in osteoblasts.

Pub. Date : 2003 Jul 1

PMID : 12801520






4 Functional Relationships(s)
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1 PD98059 and U-0126, specific inhibitors of MEK, suppressed the VEGF synthesis induced by TGF-beta. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one transforming growth factor, beta 1 Mus musculus
2 A combination with PD98059 and SB203580 almost completely suppressed the TGF-beta-induced VEGF synthesis. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one transforming growth factor, beta 1 Mus musculus
3 The amplifications by retinoic acid of TGF-beta-increased VEGF synthesis and levels of VEGF mRNA were reduced by PD98059 or SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one transforming growth factor, beta 1 Mus musculus
4 The combination of PD98059 and SB203580 almost completely suppressed the enhancement by retinoic acid of VEGF synthesis induced by TGF-beta. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one transforming growth factor, beta 1 Mus musculus